Page 6 - TBAS-may-2018

-6- TBAS May 2018 ....................
gyrodactylus could be obtained in aquarium with 10 to 15 ppm formalin over a 72
hour period (Allison, 1957).

(B) Potassium Permanganate, KMn0 4
Tests “conducted at Alabama Polytechnic Institute in Auburn, Alabama,
reported better than 99% control of gyrodactylogyrus after a single treatment of 3
to 4 ppm potassium permanganate (Allison, 1957). I have found that potassium
permanganate is stressful to juvenile discus so that formalin would probably be a
safer treatment for the less experienced aquarist.

(C) Mebendazole, C H N 0 [Fig. 2]
16
3
13
Mebendazole, 5-benzoyl-2-benizimidazolecarbamic acid methyl ester, is a
slightly yellow powder which is practically insoluble in water, alcohol, chloroform,
ether, and dilute mineral acids, but it is soluble in DMSO (dimethyl sulfoxide) and
it is freely soluble in formic acid. The LD50 (LD50 is the dosage which is lethal to
50% of the test animals) in mice, rats, and chickens exceeded 80 mg/kg. It has
been marketed under the trade names: Bantenol , Lomper, Mebenvet, Noverme,
Ovitelmin, Pantelmin, Telmin, Vermicidin , Vermirax , and Vermox (Merck, 5647
, lith Ed.) . Mebendazole 5% can be applied at 2 mg per liter (Schmitz , Sept.
1988). Mebendazole must first be dissolved in the minimum quantity of DMSO
(dimethyl sulfoxide) and the resulting solution added to the tank water. Flubenol
5%, may be substituted with less risk to the fish due to the much higher LD , see
50
Flubendazole below.

(D) Flubendazole C H FN 0 [Fig. 2 below]
3 3
16
12
Flubendazole, 5-(p-fluorobenzoyl)- 2-benzimidazolecarbamic acid methyl
ester, is simply Mebendazole with a flourine atom attached. The LD50 in mice
, rats , and guinea pigs exceeded 2560 mg/kg. It has been marketed under the
names: Flubenol, Flumoxal , Flumoxane, Fluvermal (Merck, 4050, 11th Ed.). The
German literature recommends Flubenol 5% dissolved in the minimum volume of
DMSO (dimethyl sulfoxide) be added to the tank water at 2 mg per liter (Kohler,
March 89). Flubendazole is manufactured by the Belgian Pharmaceutical firm
Janssen, but their tests have shown that no more than 80% of worm eggs are
killed, even by high doses of this compound (Kohler, June 90).

(E) Praziquantel C H N 0 [Fig. 2 below]
2 2
19
24
Praziquantel, 2-Cyc lohexylcarbonyl - 1,2,3,6,7,1 lbhexahydropyrazino [2,
1, -a] isoquinolin-4-one, occurs as a white crystalline powder which is only very
slightly soluble in water, but is soluble in alcohol. The oral LD in mice and rats
50
exceeds 2000 to 3000 mg/kg . It has been marketed under the names: Biltric ide,
To Table of Contents